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Application of the 2017 Revised McDonald Criteria for Multiple Sclerosis to Patients with a Typical Clinically Isolated Syndrome JAMA Neurol 75:1392-1398, Van Der Vuurst De Vries, R.M.,et al, 2018 See this aricle in Pubmed Article Abstract The 2017 revised McDonald criteria are associated with greater sensitivity but less specificity for a second attack than the previous 2010 criteria. The tradeoff is that it leads to a higher number of MS diagnoses in patients with a less active disease course.

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